A diversified dietary pattern is associated with a balanced gut microbial composition of Faecalibacterium and Escherichia/Shigella in patients with Crohn's disease in remission (2024)

Zhang, Z., Taylor, L., Shommu, N., Ghosh, S., Reimer, R., Panaccione, R., Kaur, S., Hyun, J. E., Cai, C., Deehan, E. C., Hotte, N., Madsen, K. L., & Raman, M. (2020). A diversified dietary pattern is associated with a balanced gut microbial composition of Faecalibacterium and Escherichia/Shigella in patients with Crohn's disease in remission. , 14(11), 1547-1557. Advance online publication. https://doi.org/10.1093/ecco-jcc/jjaa084

Zhang, Zhengxiao ; Taylor, Lorian ; Shommu, Nusrat et al. / A diversified dietary pattern is associated with a balanced gut microbial composition of Faecalibacterium and Escherichia/Shigella in patients with Crohn's disease in remission. In: . 2020 ; Vol. 14, No. 11. pp. 1547-1557.

@article{97a4c87697254259907ed81af833994d,

title = "A diversified dietary pattern is associated with a balanced gut microbial composition of Faecalibacterium and Escherichia/Shigella in patients with Crohn's disease in remission",

abstract = "BACKGROUND AND AIMS: Crohn's disease (CD) is associated with alterations in gut microbial composition and function. This controlled-intervention study investigated the relationship between patterns of dietary intake and baseline gut microbiota in CD patients in remission and examined the effects of a dietary intervention in patients consuming a non-diversified diet (NDD).METHODS: Forty outpatients with quiescent CD were recruited in Calgary, Alberta Canada. Based on 3-day food records, patients consuming a lower plant-based and higher red and processed meat-based diet were assigned to the NDD group (n=15) and received a 12-week structured dietary intervention; all other patients were assigned to the diversified diet (DD) control group (n=25) and received conventional management. Fecal microbiota composition, short chain fatty acids (SCFAs) and calprotectin were measured.RESULTS: At baseline NDD and DD groups had a different fecal microbial beta-diversity (p=0.003, PERMANOVA). NDD group had lower Faecalibacterium and higher Escherichia/Shigella relative abundances compared to the DD group (3.3±5.4% vs. 8.5±10.6%; 6.9±12.2% vs. 1.6±4.4%; p≤0.03, ANCOVA). These two genera showed a strong negative correlation (rs= -0.60, q=0.0002). Fecal butyrate demonstrated a positive correlation with Faecalibacterium (rs=0.52, q=0.002), and an inhibitory relationship with Escherichia/Shigella abundance (four-parameter sigmoidal model, R= -0.83; rs= -0.44, q=0.01), respectively. After the 12 weeks dietary intervention, no difference in microbial beta-diversity between the two groups was observed (p=0.43). The NDD group demonstrated an increase in Faecalibacterium (p<0.05, GEE), and resembled the DD group at the end of the intervention (p=0.84, t-test with permutation). We did not find association of diet with fecal SCFAs or calprotectin.CONCLUSIONS: Dietary patterns are associated with specific gut microbial compositions in CD patients in remission. A diet intervention in patients consuming a NDD modifies gut microbial composition to resemble that seen in patients consuming a DD. These results identify that diet is important in shaping the microbial dysbiosis signature in CD towards a balanced community.",

keywords = "Crohn's disease, Diversified dietary intervention, Gut microbiota",

author = "Zhengxiao Zhang and Lorian Taylor and Nusrat Shommu and Subrata Ghosh and Raylene Reimer and Remo Panaccione and Sandeep Kaur and Hyun, {Jae Eun} and Chenxi Cai and Deehan, {Edward C} and Naomi Hotte and Madsen, {Karen L} and Maitreyi Raman",

note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of European Crohn{\textquoteright}s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.",

year = "2020",

month = apr,

day = "28",

doi = "10.1093/ecco-jcc/jjaa084",

language = "English",

volume = "14",

pages = "1547--1557",

journal = "Journal of Crohn's & Colitis",

issn = "1873-9946",

publisher = "Oxford University Press",

number = "11",

}

Zhang, Z, Taylor, L, Shommu, N, Ghosh, S, Reimer, R, Panaccione, R, Kaur, S, Hyun, JE, Cai, C, Deehan, EC, Hotte, N, Madsen, KL & Raman, M 2020, 'A diversified dietary pattern is associated with a balanced gut microbial composition of Faecalibacterium and Escherichia/Shigella in patients with Crohn's disease in remission', , vol. 14, no. 11, pp. 1547-1557. https://doi.org/10.1093/ecco-jcc/jjaa084

A diversified dietary pattern is associated with a balanced gut microbial composition of Faecalibacterium and Escherichia/Shigella in patients with Crohn's disease in remission. / Zhang, Zhengxiao; Taylor, Lorian; Shommu, Nusrat et al.
In: , Vol. 14, No. 11, 28.04.2020, p. 1547-1557.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A diversified dietary pattern is associated with a balanced gut microbial composition of Faecalibacterium and Escherichia/Shigella in patients with Crohn's disease in remission

AU - Zhang, Zhengxiao

AU - Taylor, Lorian

AU - Shommu, Nusrat

AU - Ghosh, Subrata

AU - Reimer, Raylene

AU - Panaccione, Remo

AU - Kaur, Sandeep

AU - Hyun, Jae Eun

AU - Cai, Chenxi

AU - Deehan, Edward C

AU - Hotte, Naomi

AU - Madsen, Karen L

AU - Raman, Maitreyi

N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2020/4/28

Y1 - 2020/4/28

N2 - BACKGROUND AND AIMS: Crohn's disease (CD) is associated with alterations in gut microbial composition and function. This controlled-intervention study investigated the relationship between patterns of dietary intake and baseline gut microbiota in CD patients in remission and examined the effects of a dietary intervention in patients consuming a non-diversified diet (NDD).METHODS: Forty outpatients with quiescent CD were recruited in Calgary, Alberta Canada. Based on 3-day food records, patients consuming a lower plant-based and higher red and processed meat-based diet were assigned to the NDD group (n=15) and received a 12-week structured dietary intervention; all other patients were assigned to the diversified diet (DD) control group (n=25) and received conventional management. Fecal microbiota composition, short chain fatty acids (SCFAs) and calprotectin were measured.RESULTS: At baseline NDD and DD groups had a different fecal microbial beta-diversity (p=0.003, PERMANOVA). NDD group had lower Faecalibacterium and higher Escherichia/Shigella relative abundances compared to the DD group (3.3±5.4% vs. 8.5±10.6%; 6.9±12.2% vs. 1.6±4.4%; p≤0.03, ANCOVA). These two genera showed a strong negative correlation (rs= -0.60, q=0.0002). Fecal butyrate demonstrated a positive correlation with Faecalibacterium (rs=0.52, q=0.002), and an inhibitory relationship with Escherichia/Shigella abundance (four-parameter sigmoidal model, R= -0.83; rs= -0.44, q=0.01), respectively. After the 12 weeks dietary intervention, no difference in microbial beta-diversity between the two groups was observed (p=0.43). The NDD group demonstrated an increase in Faecalibacterium (p<0.05, GEE), and resembled the DD group at the end of the intervention (p=0.84, t-test with permutation). We did not find association of diet with fecal SCFAs or calprotectin.CONCLUSIONS: Dietary patterns are associated with specific gut microbial compositions in CD patients in remission. A diet intervention in patients consuming a NDD modifies gut microbial composition to resemble that seen in patients consuming a DD. These results identify that diet is important in shaping the microbial dysbiosis signature in CD towards a balanced community.

AB - BACKGROUND AND AIMS: Crohn's disease (CD) is associated with alterations in gut microbial composition and function. This controlled-intervention study investigated the relationship between patterns of dietary intake and baseline gut microbiota in CD patients in remission and examined the effects of a dietary intervention in patients consuming a non-diversified diet (NDD).METHODS: Forty outpatients with quiescent CD were recruited in Calgary, Alberta Canada. Based on 3-day food records, patients consuming a lower plant-based and higher red and processed meat-based diet were assigned to the NDD group (n=15) and received a 12-week structured dietary intervention; all other patients were assigned to the diversified diet (DD) control group (n=25) and received conventional management. Fecal microbiota composition, short chain fatty acids (SCFAs) and calprotectin were measured.RESULTS: At baseline NDD and DD groups had a different fecal microbial beta-diversity (p=0.003, PERMANOVA). NDD group had lower Faecalibacterium and higher Escherichia/Shigella relative abundances compared to the DD group (3.3±5.4% vs. 8.5±10.6%; 6.9±12.2% vs. 1.6±4.4%; p≤0.03, ANCOVA). These two genera showed a strong negative correlation (rs= -0.60, q=0.0002). Fecal butyrate demonstrated a positive correlation with Faecalibacterium (rs=0.52, q=0.002), and an inhibitory relationship with Escherichia/Shigella abundance (four-parameter sigmoidal model, R= -0.83; rs= -0.44, q=0.01), respectively. After the 12 weeks dietary intervention, no difference in microbial beta-diversity between the two groups was observed (p=0.43). The NDD group demonstrated an increase in Faecalibacterium (p<0.05, GEE), and resembled the DD group at the end of the intervention (p=0.84, t-test with permutation). We did not find association of diet with fecal SCFAs or calprotectin.CONCLUSIONS: Dietary patterns are associated with specific gut microbial compositions in CD patients in remission. A diet intervention in patients consuming a NDD modifies gut microbial composition to resemble that seen in patients consuming a DD. These results identify that diet is important in shaping the microbial dysbiosis signature in CD towards a balanced community.

KW - Crohn's disease

KW - Diversified dietary intervention

KW - Gut microbiota

UR - http://www.scopus.com/inward/record.url?scp=85087942894&partnerID=8YFLogxK

U2 - 10.1093/ecco-jcc/jjaa084

DO - 10.1093/ecco-jcc/jjaa084

M3 - Article

C2 - 32343765

SN - 1873-9946

VL - 14

SP - 1547

EP - 1557

JO - Journal of Crohn's & Colitis

JF - Journal of Crohn's & Colitis

IS - 11

ER -

Zhang Z, Taylor L, Shommu N, Ghosh S, Reimer R, Panaccione R et al. A diversified dietary pattern is associated with a balanced gut microbial composition of Faecalibacterium and Escherichia/Shigella in patients with Crohn's disease in remission. . 2020 Apr 28;14(11):1547-1557. Epub 2020 Apr 28. doi: 10.1093/ecco-jcc/jjaa084